preparation and characterization of rivastigmine transdermal patch based on chitosan microparticles

نویسندگان

mohsen sadeghi biomedical engineering group, faculty of chemical engineering, tarbiat modares university, tehran, iran.

fariba ganji biomedical engineering group, faculty of chemical engineering, tarbiat modares university, tehran, iran.

seyyed mojtaba taghizadeh novel drug delivery systems department, polymer science faculty, iran polymer and petrochemical institut, tehran, iran

bahram daraei faculty of medical science, department of toxicology, tarbiat modares university, tehran, iran.

چکیده

here we report a novel approach for preparation of a 6-day transdermal drug delivery system (tdds) as treatment for mild to moderate alzheimer’s disease. the spray drying method was used to prepare microparticles containing the anti-alzheimer drug. the content of the drug was determined by high performance liquid chromatography (hplc) method. the morphology and size range of the microparticles were determined. the stability of rivastigmine at high temperature was confirmed using ftir analysis as well as a validate hplc assay. the obtained results show that the drug was stable at high temperatures with 7 to 42% loading in the microparticles, and the higher drug concentrations of the solution injected into the spray dryer resulted in increase of the drug loading, surface drug and microparticles distortion. the tdds containing the microparticles was also prepared with microparticle to dry adhesive ratios of 5, 10 and 15% using acrylic adhesive. based on adhesion properties of the patches, gained from the probe tack and the peel adhesion 180° tests, and the 15% patch by having more drug content per unit area of the patch, and still having similar adhesion properties was compared to the microparticles-free patch of 5.1% rivastigmine salt (equivalent to the drug content of the 15% patch) from the permeation point of view by using franz cell diffusion over 6 days. the drug permeation rate from the microparticle-free patch was slower than the 15% microparticles patch, which is the result of crystallization of rivastigmine salt in the acrylic adhesive.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Preparation and Characterization of Rivastigmine Transdermal Patch Based on Chitosan Microparticles

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

متن کامل

Preparation and Characterization of Rivastigmine Transdermal Patch Based on Chitosan Microparticles

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

متن کامل

Preparation and Characterization of Rivastigmine Transdermal Patch Based on Chitosan Microparticles

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer's disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug, Rivastigmine, in combination with the natural polymer, chitosan, for transdermal drug delivery applications. The content of the drug was determined ...

متن کامل

Preparation and Characterization of Rivastigmine Loaded Chitosan Nanoparticles

Nanotechnology mediated drug delivery has been reported to enhance the drug efficacy, bioavailability, reduce toxicity and improve patient compliance by targeting the cells and tissues to produce desired pharmacological action. Aim: The purpose of the present study was to formulate and evaluate rivastigmine loaded chitosan nanoparticles for sustained release. Methods: Rivastigmine is a short ac...

متن کامل

Preparation and Characterization of Maleic Anhydride Cross-Linked Chitosan-Polyvinyl Alcohol Hydrogel Matrix Transdermal Patch

Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human body. Matrix type transdermal patches were prepared using alprazolam as a model drug and employing the combinations of chitosan-polyvinyl alcohol (CS-PVA) cross linked with Maleic anhydride. The transdermal patches were evaluated for the...

متن کامل

Metoprolol tartrate Containing Glutaraldehyde Cross-linked Chitosan- Polyvinyl pyrrolidone Matrix Transdermal Patch: Preparation and Characterization

The present study was undertaken to develop a suitable transdermal matrix patch of Metoprolol tartrate with different proportions of polyvinyl pyrrolidone (PVP) and chitosan crosslinked with glutaraldehyde (GA). The prepared transdermal patches were subjected to different physicochemical evaluations such as thickness, tensile strength, folding endurance, drug content, swellability, surface pH, ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
the iranian journal of pharmaceutical research

جلد ۱۵، شماره ۳، صفحات ۲۸۳-۲۹۴

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023